115. A Compendium of Kinetic Cell Death Modulatory Profiles Identifies Ferroptosis Regulators
Megan Conlon, Carson Poltorack, Giovanni Forcina, Alex Wells, Melodie Mallais, Alexis Kahanu, Leslie Magtanong,
Derek A. Pratt & Scott J. Dixon*
2020, Submitted manuscript (deposited on biorxiv at doi: https://doi.org/10.1101/826925).
114. Potent Ferroptosis Inhibitors Can Catalyze the Cross-Dismutation of Phospholipid-Derived Peroxyl Radicals and Hydroperoxyl Radicals
Jia-Fei Poon, Omkar Zilka & Derek A. Pratt*
Journal of the American Chemical Society 2020, 142, 14331-14342.
113. Metabolic Determinants of Cancer Cell Sensitivity to Canonical Ferroptosis Inducers
Mariluz Soula, Ross A. Weber, Omkar Zilka, Hanan Alwaseem, Konnor La, Henrik Molina,
Javier Garcia-Bermudez,* Derek A. Pratt* & Kıvanç Birsoy*
Nature Chemical Biology 2020, 16, 1351-1360.
112. Radical Substitution Provides a Unique Route to Disulfides
Zijun Wu & Derek A. Pratt*
Journal of the American Chemical Society 2020, 142, 10284-10290.
111. Quinone Methide Dimers Lacking Labile Hydrogen Atoms are Surprisingly Excellent Radical-Trapping Antioxidants
Mark A. R. Raycroft, Jean-Philippe R. Chauvin, Matthew S. Galliher, Kevin J. Romero,
Corey R. J. Stephenson* & Derek A. Pratt*
Chemical Science 2020, 11, 5676-5689.
(selected as a 'HOT Article' and Chem Sci 'Pick of the Week')
110. Reactive Sterol Electrophiles: Mechanisms of Formation and Reactions with Proteins and Amino Acid Nucleophiles
Ned A. Porter,* Libin Xu & Derek A. Pratt
Chemistry 2020, 2, 390-417.
(invited contribution to a themed issue in honour of Prof. Bernd Giese's 80th birthday)
109. Hydrogen Atom Abstraction from Polyolefins: Experimental and Computational Studies of Model Systems
Graham E. Garrett, Derek A. Pratt & J. Scott Parent*
Macromolecules 2020, 53, 2793-2800.
108. Synthesis of Vitisin A & D: Thermal Isomerization Enabled by a Persistent Radical Equilibrium
Kevin J. Romero, Mitchell H. Keylor, Markus Griesser, Xu Zhu, Ethan J. Strobel,
Derek A. Pratt* & Corey R. J. Stephenson*
Journal of the American Chemical Society 2020, 142, 6499-6504.
107. Base-Promoted C-C Bond Activation Enables Radical Allylation with Homoallylic Alcohols
Maximilian Lübbesmeyer, Emily G. Mackay, Mark A. R. Raycroft, Jonas Elfert,
Derek A. Pratt* & Armido Studer*
Journal of the American Chemical Society 2020, 142, 2609-2616.
106. On the Products of Cholesterol Autoxidation in Phospholipid Bilayers and the
Formation of Secosterols Derived Therefrom
Emily L. Schaefer, Nadia Zopyrus, Zosia A. M. Zielinski, Glenn A. Facey & Derek A. Pratt*
Angewandte Chemie International Edition 2020, 59, 2089-2094.
(selected as a 'Very Important Paper')
105. The Chemical Basis of Ferroptosis
Marcus Conrad* & Derek A. Pratt*
Nature Chemical Biology 2019, 15, 1137-1147.
(commissioned Perspective)
104. FSP1 is a Glutathione-Independent Ferroptosis Suppressor
Sebastian Doll, Florencio Porto Freitas, Ron Shah, Maceler Aldrovandi, Milene Costa da Silva, Irina Ingold, Andrea Goya Grocin, Elena Panzilius, Christina Scheel, André Mourão, Katalin Buday, Jonas Wanninger, Thibaut Vignane, Vaishnavi Mohana, Markus Rehberg, Andrew Flatley, Aloys Schepers, Andreas Kurz, Daniel White, Markus Sauer, Michael Sattler, Edward William Tate, Werner Schmitz, Almut Schulze, Valerie O’Donnel, Bettina Proneth, Grzegorz M. Popowicz, Derek A. Pratt, José Pedro Friedmann Angeli* & Marcus Conrad*
Nature 2019, 575, 693-698.
(See related Nature News & Views on this manuscript)
103. Beyond DPPH: Use of Fluorescence-ENabled Inhibited AutoXidation (FENIX) Predicts Oxidative Cell Death Rescue
Ron Shah, Luke A. Farmer, Omkar Zilka, Antonius T. M. Van Kessel & Derek A. Pratt*
Cell Chemical Biology 2019, 26, 1594-1607.
(Selected as a feature article; see highlight 'Dawn of a New Era of Targeted Antioxidant Therapy' in Cell Chemical Biology)
102. Threshold Protective Effect of Deuterated Polyunsaturated Fatty Acids on the Peroxidation of Lipid Bilayers
Alexander M. Firsov, Maksim A. Fomich, Andrei V. Bekish, Olga L. Sharko, Elena A. Kotova, Harry J. Saal, Dragoslav Vidovic, Vadim V. Shmanai, Derek A. Pratt, Yuri N. Antonenko* & Mikhail S. Shchepinov*
FEBS Journal 2019, 286, 2099-2117.
101. The Antioxidant Activity of Polysulfides: It’s Radical!
Jean-Philippe R. Chauvin, Markus Griesser & Derek A. Pratt*
Chemical Science
2019, 10, 4999-5010.
(Selected as a 'Hot Article' and highlighted in RSC's Chemistry World)
100. H-Atom Abstraction vs. Addition: Accounting for the Diverse Product Distribution in the Autoxidation of Cholesterol & its Esters
Zosia A. M. Zielinski & Derek A. Pratt*
Journal of the American Chemical Society 2019, 141, 3037-3051.
#99
Electrochemical Dimerization of Phenylpropenoids and the Surprising Antioxidant Activity of the Resultant Quinone Methide Dimers
Kevin J. Romero, Matthew S. Galliher, Mark A. R. Raycroft, Jean-Philippe R. Chauvin, Irene Bosque, Derek A. Pratt* & Corey R. J. Stephenson*
Angewandte Chemie International Edition
2018, 57, 17125-17129.
#98
Radicals in Natural Product Synthesis
Kevin J. Romero, Matthew S. Galliher, Derek A. Pratt* & Corey R. J. Stephenson*
Chemical Society Reviews
2018, 47, 7851-7866.
(invited tutorial review)
#97
The Hydrogen Atom Transfer Reactivity of Sulfinic Acids
Markus Griesser, Jean-Philippe R. Chauvin & Derek A. Pratt*
Chemical Science
2018, 9, 7218-7229.
#96
Recent Insights on Hydrogen Atom Transfer in the Inhibition of Hydrocarbon Autoxidation
Jia-Fei Poon & Derek A. Pratt*
Accounts of Chemical Research
2018, 51, 1996-2005.
(invited contribution for special issue on H-Atom Transfer)
#95
Inhibition of Hydrocarbon Autoxidation by Nitroxide-Catalyzed Cross-Dismutation of Hydroperoxyl and Alkylperoxyl Radicals
Kareem A. Harrison, Evan A. Haidasz, Markus Griesser & Derek A. Pratt*
Chemical Science
2018, 9, 6068-6079.
#94
Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis
Ron Shah, Mikhail S. Shchepinov & Derek A. Pratt*
ACS Central Science
2018, 4, 387-396.
#93
The Catalytic Reaction of Nitroxides with Peroxyl Radicals and its Relevance to their Cytoprotective Properties
Markus Griesser, Ron Shah, Antonius T. Van Kessel, Omkar Zilka, Evan A. Haidasz & Derek A. Pratt*
Journal of the American Chemical Society
2018, 140, 3798-3808.
#92
Phenoxazine: A Privileged Scaffold for Radical-Trapping Antioxidants
Luke A. Farmer, Evan A. Haidasz, Markus Griesser & Derek A. Pratt*
Journal of Organic Chemistry
2017, 82, 10523-10536.
#91
Ron Shah, Kaitlyn D. Margison & Derek A. Pratt*
ACS Chemical Biology
2017, 12, 2538-2545.
#90
Hydropersulfides: H-Atom Transfer Agents Par Excellence
Jean-Philippe R. Chauvin, Markus Griesser & Derek A. Pratt*
Journal of the American Chemical Society
2017, 139, 6484-6493.
#89
Diazaphenoxazines and Diazaphenothiazines: Synthesis of the ‘Correct’ Isomers Reveals They are Highly-Reactive Radical-Trapping Antioxidants
Evan A. Haidasz & Derek A. Pratt*
Organic Letters
2017, 19, 1854-1857.
#88
Aminyl Radical Generation via Tandem Norrish Type I Photocleavage, β-Fragmentation: Independent Generation and Reactivity of the 2'-Deoxyadenosin- N6-yl Radical
Liwei Zheng, Markus Griesser, Derek A. Pratt* & Marc M. Greenberg*
Journal of Organic Chemistry
2017, 82, 3571-3580.
#87
Lipid Peroxidation: Kinetics, Mechanisms and Products
Zosia A. M. Zielinski & Derek A. Pratt*
Journal of Organic Chemistry
2017, 82, 2817-2825.
(invited Synopsis)
#86
Ferroptosis Inhibition: Mechanisms and Opportunities
José Pedro Friedmann Angeli,* Ron Shah, Derek A. Pratt* & Marcus Conrad*
Trends in Pharmacological Sciences
2017, 38, 489-498.
#85
On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death
Omkar Zilka, Ron Shah, Bo Li, José Pedro Friedmann Angeli, Markus Griesser, Marcus Conrad & Derek A. Pratt*
ACS Central Science
2017, 3, 232-243.
#84
On the Reactions of Thiols, Sulfenic Acids and Sulfinic Acids with Hydrogen Peroxide
Jean-Philippe R. Chauvin & Derek A. Pratt*
Angewandte Chemie International Edition
2017, 56, 6255-6259.
(Part of the Special Issue: 100th Anniversary of the Canadian Society for Chemistry)
#83
Synthesis of Resveratrol Tetramers via a Stereoconvergent Radical Equilibrium
Mitchell H. Keylor, Bryan S. Matsuura, Markus Griesser, Jean-Philippe R. Chauvin,
Ryan A. Harding, Mariia S. Kirillova, Xu Zhu, Oliver J. Fischer,
Derek A. Pratt* & Corey R. J. Stephenson*
Science
2016, 354, 1260-1265.
#82
Determination of Key Hydrocarbon Autoxidation Products by Fluorescence
Ron Shah & Derek A. Pratt*
Journal of Organic Chemistry
2016, 81, 6649-6656.
#81
Polysulfide-1-Oxides React with Peroxyl Radicals as Quickly as Hindered Phenolic Antioxidants and do so by a Surprising Concerted Homolytic Substitution at Sulfur
Jean-Philippe R. Chauvin, Evan A. Haidasz, Markus Griesser & Derek A. Pratt*
Chemical Science
2016, 7, 6347-6356.
#80
Cholesterol Autoxidation Revisited: Debunking the Dogma Associated With the Most Vilified of Lipids
Zosia A. M. Zielinski & Derek A. Pratt*
Journal of the American Chemical Society
2016, 138, 6932-6935.
(Selected for a 'JACS Spotlight')
(Chosen as a "Selected Articles of 2016" by the Associate Editors of JACS)
#79
Acid is Key to the Radical-Trapping Antioxidant Activity of Nitroxides
Evan A. Haidasz, Derek Meng, Riccardo Amorati, Andrea Baschieri, Keith U. Ingold,
Luca Valgimigli* & Derek A. Pratt*
Journal of the American Chemical Society
2016, 138, 5290-5298.
#78
A Continuous Visible Light Spectrophotometric Approach to Accurately Determine the Reactivity of Radical-Trapping Antioxidants
Evan A. Haidasz, Antonius T. M. Van Kessel & Derek A. Pratt*
Journal of Organic Chemistry
2016, 81, 737-744.
(Selected as a 'Featured Article' and 'Cover Article')
#77
Inspired by Garlic: Insights on the Chemistry of Sulfenic Acids and the Radical-Trapping Antioxidant Activity of Organosulfur Compounds
Jean-Philippe R. Chauvin, Zosia Zielinski & Derek A. Pratt*
Canadian Journal Chemistry
2016, 94, 1-8.
(Invited minireview in recognition of the 2015 CSC Fagnou Award)
#76
The Medicinal Thiosulfinates from Garlic and Petiveria Are Not Radical-Trapping Antioxidants in Liposomes and Cells, but Lipophilic Analogs Are
Bo Li, Feng Zheng, Jean-Philippe R. Chauvin & Derek A. Pratt*
Chemical Science
2015, 6 , 6165-6178.
(Highlighted in Chemistry World)
#75
Maximizing the Reactivity of Phenolic and Aminic Radical-Trapping Antioxidants: Just Add Nitrogen!
Luca Valgimigli* & Derek A. Pratt*
Accounts of Chemical Research
2015, 48, 966-975.
(invited contribution)
#74
Methods for Determining the Efficacy of Radical-Trapping Antioxidants
Bo Li & Derek A. Pratt*
Free Radical Biology and Medicine
2015, 82, 187-202.
(invited contribution)
#73
Unprecedented Inhibition of Hydrocarbon Autoxidation by Diarylamine Radical-Trapping Antioxidants
Ron Shah, Evan A. Haidasz, Luca Valgimigli & Derek A. Pratt*
Journal of the American Chemical Society
2015, 137, 2440-2443.
(selected for a 'JACS spotlight')
#72
A Scalable Biomimetic Synthesis of Resveratrol Dimers and Systematic Evaluation of their Antioxidant Activities
Bryan S. Matsuura, Mitchell H. Keylor, Bo Li, YuXuan Lin, Shelby Allison,
Derek A. Pratt* & Corey R. J. Stephenson*
Angewandte Chemie International Edition
2015, 54, 3754-3757.
(selected as a 'hot paper' by Angewandte Chemie and highlighted in Nature Chemistry)
#71
The Catalytic Mechanism of Diarylamine Radical-Trapping Antioxidants.
Evan A. Haidasz, Ron Shah and Derek A. Pratt*
Journal of the American Chemical Society
2014, 136, 16643-16650.
(selected for a 'JACS spotlight')
#70
Advances in Radical-Trapping Antioxidant Chemistry in the 21st Century: A Kinetics and Mechanisms Perspective.
Keith U. Ingold* and Derek A. Pratt*
Chemical Reviews
2014, 114, 9022-9046.
#69
Reactivity of Polyolefins Towards Cumyloxyl Radical: Yields and Regioselectivity of Hydrogen Atom Transfer.
Graham E. Garrett, Elena Mueller, Derek A. Pratt and J. Scott Parent*
Macromolecules
2014, 47, 544-551.
#68
Redox Chemistry of Selenenic Acids and the Inisight it Brings on Transition State Geometry in the Reactions of Peroxyl Radicals.
Zosia Zielinski, Nathalie Presseau, Riccardo Amorati, Luca Valgimigli* and Derek A. Pratt*
Journal of the American Chemical Society
2014, 136, 1570-1578.
#67
3-Pyridinols and 5-Pyrimidinols: Tailor-Made for Use in Synergistic Radical-Trapping Co-Antioxidant Systems
Luca Valgimigli,* Daniela Bartolomei, Riccardo Amorati, Evan Haidasz, Jason J. Hanthorn, Susheel J. Nara, Johan Brinkhorst and Derek A. Pratt*
Beilstein Journal of Organic Chemistry
2013, 9, 2781-2792.
#66
Reaction Mechanisms: Radical and Radical Ion Reactions
Evan Haidasz, Bo Li & Derek A. Pratt*
Royal Society of Chemistry, Annual Reports on Progress in Chemistry, Section B
2013, 109, 295-327.
(invited contribution)
#65
Radical-Trapping Antioxidant Generation and Regeneration: The Amazing Combination of Lipophilic Thiosulfinates and Hydrophilic Thiols
Feng Zheng and Derek A. Pratt*
Chemical Communications
2013, 49, 8181-8183.
#64
Besting Vitamin E: Sidechain Substitution is Key to the Reactivity of Naphthyridinol Antioxidants in Lipid Bilayers
Bo Li, Jitendra R. Harjani, Nicholas S. Cormier, Hasam Madarati, Jeffrey Atkinson, Gonzalo Cosa &
Derek A. Pratt*
Journal of the American Chemical Society
2013, 135, 1394-1405.
#63
A Versatile Fluorescence Approach to Kinetic Studies of Hydrocarbon Autoxidations and their Inhibition by Radical-Trapping Antioxidants
Jason J. Hanthorn, Evan Haidasz, Paul Gebhardt & Derek A. Pratt*
Chemical Communications
2012, 48, 10141-10143.
#62
The Reactivity of Air-Stable Pyridine- and Pyrimidine-Containing Diarylamine Antioxidants
Jason J. Hanthorn, Riccardo Amorati, Luca Valgimigli,* & Derek A. Pratt*
Journal of Organic Chemistry
2012, 77, 6895-6907.
#61
The Preparation of Highly Reactive Pyridine- and Pyrimidine-Containing Diarylamine Antioxidants
Jason J. Hanthorn, Luca Valgimigli, & Derek A. Pratt*
Journal of Organic Chemistry
2012, 77, 6908-6916.
#60
Dissecting the Mechanisms of a Class of Chemical Glycosylation Using Primary 13C Kinetic Isotope Effects
Min Huang, Graham E. Garrett, Nicolas Birlirakis, Luis Bohé, Derek A. Pratt* & David Crich*
Nature Chemistry
2012, 4, 663-667.
#59
The Reaction of Sulfenic Acids with Peroxyl Radicals: Insights into the Radical-Trapping Antioxidant Activity of Plant-Derived Thiosulfinates
Riccardo Amorati, Philip T. Lynett, Luca Valgimigli* & Derek A. Pratt*
Chemistry - A European Journal
2012, 18, 6370-6379.
#58
The Effect of Ring Nitrogens on the Radical-Trapping Activity of Diphenylamine Antioxidants; Striking a Balance Between Reactivity and Stability
Jason J. Hanthorn, Luca Valgimigli* & Derek A. Pratt*
Journal of the American Chemical Society
2012, 134, 8306-8308.
#57
Peroxyesters as Precursors to Peroxyl Radical Clocks
Jason J. Hanthorn & Derek A. Pratt*
Journal of Organic Chemistry
2012, 77, 276-284.
#56
A Selective Cysteinyl Leukotriene Receptor 2 Antagonist Blocks Myocardial Ischemia/Reperfusion Injury and Vascular
Permeability in Mice
Nathan C. Ni, Dong Yan, Laurel L. Ballantyne, Alma Barajas-Espinosa, Tim St. Amand, Derek A. Pratt & Colin D. Funk*
Journal of Pharmacology and Experimental Therapeutics
2011, 339, 768-778.
#55
Hyperconjugation Contributes to the Bimodal Distribution of Glycine Conformations Observed in Protein 3-Dimensional Structures
Brent Wathen, Derek A. Pratt* & Zongchao Jia*
ChemBioChem
2011, 12, 1674-1677.
#54
Free Radical Oxidation of Polyunsaturated Lipids: New Mechanistic Insights and the Development of Peroxyl Radical Clocks
Derek A. Pratt, Keri A. Tallman & Ned A. Porter*
Accounts of Chemical Research
2011, 44, 458-467.
#53
The Mechanism of Antioxidant Activity of Plant-Derived Thiosulfinates
Philip T. Lynett, Krista Butts, Vipraja Vaidya, Graham E. Garrett & Derek A. Pratt*
Organic and Biomolecular Chemistry
2011, 9, 3320-3330.
(invited contribution to special issue in memory of Athel Beckwith)
#52
Autoxidative and -2 Catalyzed Transformation of the Dietary Chemopreventive Agent Curcumin
Markus Griesser, Valentina Pistis, Takashi Suzuki, Noemi Tejera, Derek A. Pratt & Claus Schneider*
Journal of Biological Chemistry
2011, 286, 1114-1124.
#51
The Redox Chemistry of Sulfenic Acids
Alaina J. McGrath, Graham E. Garrett, Luca Valgimigli* & Derek A. Pratt*
Journal of the American Chemical Society
2010, 132, 16759-16761.
#50
Preparation and Investigation of Vitamin B6-Derived Aminopyridinol Antioxidants
Remi Serwa, Tae-Gyu Nam, Luca Valgimigli, Sean Culbertson, Christopher L. Rector, Byeong-Seon Jeong,* Derek A. Pratt* & Ned A. Porter
Chemistry - A European Journal
2010, 16, 14106-14114.
#49
Isomerization and Elimination Reactions of Brominated Poly(isobutylene-co-isoprene)
Sean Malmberg, J. Scott Parent, Derek A. Pratt & Ralph A. Whitney*
Macromolecules
2010, 43, 8456-8461.
#48
Influence of Remote Intramolecular Hydrogen Bonds on the Stabilities of Phenoxyl Radicals and Benzyl Cations
Mario C. Foti,* Riccardo Amorati* Gian Franco Pedulli, Carmelo Daquino, Derek A. Pratt & Keith U. Ingold
Journal of Organic Chemistry
2010, 75, 4434-4440.
#47
TEMPO Reacts with Oxygen-Centered Radicals Under Acidic Conditions
Riccardo Amorati, Gian Franco Pedulli, Derek A. Pratt* & Luca Valgimigli*
Chemical Communications
2010, 46, 5139-5141.
#46
Secondary Orbital Interactions in the Propagation Steps of Lipid Peroxidation
Di Hu & Derek A. Pratt*
Chemical Communications
2010, 46, 3711-3713.
#45
Tyrosine Analogues for Probing Proton-Coupled Electron Transfer Processes in Peptides and Proteins
Susheel J. Nara, Luca Valgimigli,* Gian Franco Pedulli & Derek A. Pratt*
Journal of the American Chemical Society
2010, 132, 863-872.
#44
Pyridine and Pyrimidine Analogs of Acetaminophen as Inhibitors of Lipid Peroxidation and Cyclooxygenase and Lipoxygenase Catalysis
Tae-Gyu Nam, Susheel J. Nara, Irene Zagol-Ikapitte, Tom Cooper, Luca Valgimigli, John A. Oates, Ned A. Porter, Olivier Boutaud* & Derek A. Pratt*
Organic and Biomolecular Chemistry
2009, 7, 5103-5112.
#43
Unexpected Acid Catalysis in Reactions of Peroxyl Radicals with Phenols
Luca Valgimigli,* Riccardo Amorati, Sylvia Petrucci, Gian Franco Pedulli, Di Hu, Jason J. Hawthorn & Derek A. Pratt*
Angewandte Chemie International Edition
2009, 48, 8348-8351.
#42
Synthesis of Pyrrolnitrin and Related Halogenated Phenylpyrroles
Matthew D. Morrison, Jason J. Hanthorn & Derek A. Pratt*
Organic Letters
2009, 11, 1051-1054.
#41
Garlic: Source of the Ultimate Antioxidants – Sulfenic Acids
Vipraja Vaidya, Keith U. Ingold & Derek A. Pratt*
Angewandte Chemie International Edition
2009, 48, 157-160.
(highlighted in Science Daily and media around the globe)
#40
A Simple Cu-Catalyzed Coupling Approach to Substituted 3-Pyridinol and 5-Pyrimidinol Antioxidants
Susheel J. Nara, Mukund Jha, Johan Brinkhorst, Tony Zemanek & Derek A. Pratt*
Journal of Organic Chemistry
2008, 73, 9326-9333.
#39
Hock Cleavage of Cholesterol 5α-Hydroperoxide: An Ozone-Free Pathway to the Cholesterol Ozonolysis Products Identified in Arterial Plaque and Brain Tissue
Johan Brinkhorst, Susheel J. Nara & Derek A. Pratt*
Journal of the American Chemical Society
2008, 130, 12224-12225.
#38
Kinetic Solvent Effects on Peroxyl Radical Reactions
Mukund Jha & Derek A. Pratt*
Chemical Communcations
2008, 44, 1252-1254.
#37
The Unusual Reaction of Semiquinone Radicals with Molecular Oxygen
Luca Valgimigli,* Riccardo Amorati, Maria Grazio Fumo, Gino A. DiLabio, Gian Franco Pedulli, Keith U. Ingold & Derek A. Pratt*
Journal of Organic Chemistry
2008, 73, 1830-1841.
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