​

Sex-Specific Expression of Estradiol Derivatives, Hydropersulfides and Ether Lipids

Regulates Ferroptosis Sensitivity of Kidney Tubules 

Alexia Belavgeni, Wulf Tonnus, Francesca Maremonti, Sider Penkov, Melodie Mallais, Christine Gaillet, Anne Brucker, Danny Schilling, Lisa Schlicker, Nina Himmerkus, Shubhangi Gavali, Marlena Schlecht, Karolin Flade, Jorunn Naila Becker, Mirela Tmava, Anne Haag, Christian Hugo, Almut Schulze, Bernd Plietker, Jan Ulrich Becker, Joel M. Weinberg, Bettina Proneth, Marcus Conrad, Raphael Rodriguez, Stefan R. Bornstein, Tobias P. Dick, Derek A. Pratt, Maria Fedorova & Andreas Linkermann*

Submitted

​

Attenuating N-oxyl Decomposition for Improved Hydrogen Atom Transfer Catalysts Design

Cheng Yang, Luke A. Farmer, Elvis M. McFee, Rahul Jah, Stephen Maldonado,* Derek A. Pratt* & Corey R. J. Stephenson*

Submitted

​

Interrupted Homolytic Substitution Enables Organoboron Compounds to

Inhibit Radical Chain Reactions Rather than Initiate Them

Zijun Wu, Robyn Vlaming, Michael Donohoe & Derek A. Pratt* 

Submitted (click title to see Sneak Peek)

​

Revisiting the Reactivity of the Dismissed Hydrogen Atom Transfer Catalyst Succinimide-N-oxyl 

Cheng Yang, Luke A. Farmer, Derek A. Pratt,* Stephen Maldonado,* & Corey R. J. Stephenson*

Submitted

​

138. Enhancement of Diarylamine Antioxidant Activity by Molybdenum Dithiocarbamates

Carly S. Hanson, Michael Donohoe & Derek A. Pratt* 

Journal of Organic Chemistry, accepted

​

137. 7-Dehydrocholesterol is an Endogenous Suppressor of Ferroptosis 

Florencio Porto Freitas, Palina Nepachalovich, Lohans P. Puentes, Omkar Zilka, Alex Inague, Svenja M. Lorenz, Viktoria Kunz,

Helene Nehring, Thamara N. Xavier da Silva, Zhiyi Chen, Sebastian G. Doll, Werner Schmitz, Aline Horling, Peter Imming,

Sayuri Miyamoto, Ann Wehmann, Thiago C. Genaro-Mattos, Karoly Mirnics, Lokender Kumar, Judith Klein-Seetharaman,

Svenja Meierjohann, Isabel Weigand, Matthias Kroiss, Georg W. Bornkamm, Kurt Bommert, Ralf C. Bargou, Ana Garcia-Saez,

Derek A. Pratt, Maria Fedorova, Marcus Conrad, José Pedro Friedmann Angeli*

Nature, accepted (click title to see bioarxiv preprint)

​

2023

​

136. Photocatalytic C-S Bond Formation Using N-Thiophthalimide and N-Perthiophthalimide Derivatives

Hsin-Ju Huang, Zijun Wu & Derek A. Pratt* 

ACS Catalysis 2023, 13, 13912-13919

​

135. Intramolecular H-Atom Transfers in Alkoxyl Radical Intermediates Underlie the

Apparent Oxidation of Lipid Hydroperoxides by Fe(II)

Dmitry D. Saraev, Zijun Wu, Hye-Young Kim, Ned A. Porter & Derek A. Pratt* 

ACS Chemical Biology 2023,18, 2073-2081

​

134. Leveraging the Persistent Radical Effect in the Synthesis of Trans-2,3-Diaryl-Dihydrobenzofurans

Bec J. Roldan, Travis A. Hammerstad, Matthew S. Galliher, Mitchell H. Keylor, Derek A. Pratt* & Corey R. J. Stephenson* 

Angewandte Chemie International Edition 2023, 62, e202305801

​

133. Development of PINO-Derived Hydrogen Atom Transfer Catalysts

Cheng Yang, Sahil Arora, Stephen Maldonado,* Derek A. Pratt* & Corey R. J. Stephenson* 

Nature Reviews Chemistry 2023, 7, 653-666

​

132. Targeting Lipoxygenases to Suppress Ferroptotic Cell Death

Derek A. Pratt* 

Proceedings of the National Academy of Sciences 2023, 120, e2309317120

 

131. Emergence of (Hydro)persulfides as Suppressors of Lipid Peroxidation and Ferroptotic Cell Death

Zijun Wu, Uladzimir Barayeu, Danny Schilling, Tobias P. Dick* & Derek A. Pratt*

Current Opinion in Chemical Biology 2023, 76, 102353

​

130. Radical Approaches to C-S Bonds

Zijun Wu & Derek A. Pratt* 

Nature Reviews Chemistry 2023, 7, 573-589

​

129. vPIF-1 is an Insulin-Like Anti-Ferroptotic Viral Peptide

Alexia Belavgeni, Francesca Maremonti, Wulf Tonnus, Marlena Stadtmüller, Shubhangi Gavali, Melodie Mallais, Karolin Flade,

Anne Brucker, Jorunn Naila Becker, Kristina Beer, Mirela Tmava, Julian Stumpf, Florian Gembardt, Christian Hugo, Mauro Giacca,

Benjamin G. Hale, Nikolaos Perakakis, Wei Sha, Derek A. Pratt, Andrew V. Schally, Stefan R. Bornstein* & Andreas Linkermann*

Proceedings of the National Academy of Sciences 2023,120, e2300320120

 

128. Ferroptosis: A Flexible Constellation of Related Biochemical Mechanisms

Scott J. Dixon* & Derek A. Pratt* 

Molecular Cell 2023, 83, 1030-1042

​

127. General Approach to Identify, Assess and Characterize Inhibitors of

Lipid Peroxidation and Associated Cell Death

Melodie Mallais, Carly S. Hanson, Melanie Giray & Derek A. Pratt* 

ACS Chemical Biology 2023, 18, 561-571

​

2022

​

126. Hydropersulfides Inhibit Lipid Peroxidation and Protect Cells From Ferroptosis

Zijun Wu, Vinayak S. Khodade, Jean-Philippe R. Chauvin, Deborah Rodriguez, John P. Toscano & Derek A. Pratt* 

Journal of the American Chemical Society 2022, 144, 15825-15837

(featured in Nature Chemical Biology ‘News and Views’ and a 'Spotlight' in Cell Chemical Biology)

​

125. Intrinsic & Extrinsic Limitations to the Design and Optimization of Inhibitors

of Lipid Peroxidation and Associated Cell Death

Luke A. Farmer, Zijun Wu, Jia-Fei Poon, Omkar Zilka, Svenja M. Lorenz, Stephanie Huehn,

Bettina Proneth, Marcus Conrad & Derek A. Pratt* 

Journal of the American Chemical Society 2022, 144, 14706-14721

​

124. A Non-Canonical Vitamin K Cycle is a Potent Ferroptosis Suppressor

Eikan Mishima,* Junya Ito, Zijun Wu, Toshitaka Nakamura, Sebastian Doll, Wulf Tonnus, Palina Nepachalovich, Elke Eggenhofer,

Maceler Aldrovandi, Bernhard Henkelmann, Ken-ichi Yamada, Jonas Wanninger, Adam Wahida, Omkar Zilka, Emiko Sato,

Regina Feederle, Daniela Hass, Adriano Maida, André Santos Dias Mourão, Andreas Linkermann, Edward K. Geissler,

Kiyotaka Nakagawa, Takaaki Abe, Maria Fedorova, Bettina Proneth, Derek A. Pratt & Marcus Conrad*

Nature 2022, 608, 778-783

(featured in Nature ‘News and Views’ and a 'Spotlight' in Molecular Cell)

 

123. Mechanism of Visible-Light Mediated Alkene Aminoarylation with Arylsulfonylacetamides

Anthony R. Allen, Jia-Fei Poon, Rory C. McAtee, Nicholas B. Watson, Derek A. Pratt* & Corey R.J. Stephenson*

ACS Catalysis 2022,12, 8511-8526

​

2021

​

122. The Radical-Trapping Antioxidant Activity of Copper and Nickel bis(Thiosemicarbazone) Complexes

Underlies Their Potency as Inhibitors of Ferroptotic Cell Death

Omkar Zilka, Jia-Fei Poon & Derek A. Pratt*

Journal of the American Chemical Society 2021, 143, 19043-19057

​

121. Temperature-Dependence of Radical-Trapping Activity of Phenoxazine, Phenothiazine and their

Aza-Analogues Clarifies the Way Forward for New Antioxidant Design

Jia-Fei Poon, Luke A. Farmer, Evan A. Haidasz & Derek A. Pratt*

Chemical Science 2021, 12, 11065-11079

​

120. Dysfunction of the Key Ferroptosis-Surveilling Systems Hypersensitizes Mice to Massive

Tubular Necrosis During Acute Kidney Injury

Wulf Tonnus, Claudia Meyer, Christian Steinebach, Alexia Belavgeni, Anne von Mässenhausen, Nadia Zamora Gonzalez,

Florian Gembardt, Nina Himmerkus, Francesca Maremonti, Markus Latk, Sophie Locke, Sebastian Doll, Spencer Short, Irina Ingold, Bettina Proneth, Kerstin Amann, Christoph Daniel, Nazanin Kabgani, Rafael Kramann, Paul Hergenrother, Stefan R. Bornstein,

Christian Hugo, Jan Ulrich Becker, Michael Gütschow, Derek Pratt, Marcus Conrad & Andreas Linkermann*

Nature Communications 2021, 12, 4402

 

119. On the Mechanism of Electrochemical Generation and Decomposition of Phthalimide N-oxyl (PINO)

Cheng Yang, Luke A. Farmer, Derek A. Pratt,* Stephen Maldonado* & Corey R. J. Stephenson*

Journal of the American Chemical Society 2021, 143, 10324-10332

​

118. Autoxidation vs. Antioxidants - The Fight for Forever

Julian Helberg & Derek A. Pratt*

Chemical Society Reviews 2021, 50, 7343-7358

(invited contribution to themed collection on radical chemistry)

​

117. A Divergent Strategy for Site-Selective Radical Disulfuration of Carboxylic Acids with Trisulfide-1,1-Dioxides

Zijun Wu & Derek A. Pratt*

Angewandte Chemie International Edition 2021, 60, 15598-15605

(highlighted in Synform)

​

116. Temperature-Dependent Effects of Alkyl Substitution on Diarylamine Radical-Trapping Antioxidant Activity 

Ron Shah, Jia-Fei Poon, Evan A. Haidasz & Derek A. Pratt*

Journal of Organic Chemistry 2021, 86, 6538-6550

​

115. A Compendium of Cell Death Modulatory Profiles Identifies Ferroptosis Regulators

Megan Conlon, Carson Poltorack, Giovanni Forcina, Alex Wells, Melodie Mallais, Alexis Kahanu, Leslie Magtanong,

Derek A. Pratt & Scott J. Dixon*

Nature Chemical Biology 2021,17, 665-674

(highlighted in Nature Chemical Biology 'News and Views')

​

2020

​

114. Potent Ferroptosis Inhibitors Can Catalyze the Cross-Dismutation of Phospholipid-Derived

Alkylperoxyl Radicals and Hydroperoxyl Radicals

Jia-Fei Poon, Omkar Zilka & Derek A. Pratt*

Journal of the American Chemical Society 2020, 142, 14331-14342

​

113. Metabolic Determinants of Cancer Cell Sensitivity to Distinct Modes of Ferroptosis

Mariluz Soula, Ross A. Weber, Omkar Zilka, Hanan Alwaseem, Konnor La, Henrik Molina, Javier Garcia-Bermudez,*

Derek A. Pratt* & Kıvanç Birsoy*

Nature Chemical Biology 2020, 16, 1351-1360

​

112. Radical Substitution on Tetrasulfides: A Unique Route to Disulfides 

Zijun Wu & Derek A. Pratt*

Journal of the American Chemical Society 2020, 142, 10284-10290

​

111. Persistent Quinone Methide Dimers Lacking Labile H-Atoms Are Surprisingly Excellent

Radical-Trapping Antioxidants

Mark A. R. Raycroft, Jean-Philippe R. Chauvin, Matthew S. Galliher, Kevin J. Romero,

Corey R. J. Stephenson* & Derek A. Pratt*

Chemical Science 2020, 11, 5676-5689

(selected by the editors as a ‘Hot Article’ and ‘Pick of the Week’)

​

110. Reactive Sterol Electrophiles: Mechanisms of Formation and Reactions with

Proteins and Amino Acid Nucleophiles 

Ned A. Porter,* Libin Xu & Derek A. Pratt

Chemistry 2020, 2, 390-417

(invited contribution to themed issue in honour of Prof. Bernd Giese’s 80th birthday)

​

109. Hydrogen Atom Abstraction from Polyolefins: Experimental and Computational Studies of Model Systems

Graham E. Garrett, Derek A. Pratt & J. Scott Parent*

Macromolecules 2020, 53, 2793-2800

​

108. Synthesis of Vitisin A & D: Thermal Isomerization Enabled by a Persistent Radical Equilibrium 

Kevin J. Romero, Mitchell H. Keylor, Xu Zhu, Ethan J. Strobel,

Derek A. Pratt* & Corey R. J. Stephenson*

Journal of the American Chemical Society 2020, 142, 6499-6504

​

107. Base-Promoted C-C Bond Activation Enables Radical Allylation with Homoallylic Alcohols

Maximilian Lübbesmeyer, Emily G. Mackay, Mark A. R. Raycroft, Jonas Elfert, Derek A. Pratt* & Armido Studer*

Journal of the American Chemical Society 2020, 142, 2609-2616

​

106. On the Products of Cholesterol Autoxidation in Phospholipid Bilayers and the Formation of

Secosterols Derived Therefrom 

Emily L. Schaefer, Nadia Zopyrus, Zosia A. M. Zielinski & Derek A. Pratt*

Angewandte Chemie International Edition 2020, 59, 2089-2094

(selected by the editors as a ‘Very Important Paper’)

​

2019

​

105. The Chemical Basis of Ferroptosis

Marcus Conrad* & Derek A. Pratt*

Nature Chemical Biology 2019, 15, 1137-1147

(commissioned ‘Perspective’; highlighted in MedicalXpress)

​

104. FSP1 is a Glutathione-Independent Ferroptosis-Suppressor

Sebastian Doll, Florencio Porto Freitas, Ron Shah, Milene Costa da Silva, Irina Ingold, Andrea Goya Grocin, Elena Panzilius, Christina Scheel, Katalin Buday, Jonas Wanninger, Thibaut Vignane, Vaishnavi Mohana, Van Lam, Aloys Schepers, Valerie O’Donnel, Maceler Aldrovandi, Michael Sattler, Edward William Tate, Bettina Proneth, Werner Schmitz, Almut Schulze, Gregorz Popowicz,

Derek A. Pratt, José Pedro Friedmann Angeli,* Marcus Conrad*

Nature 2019, 575, 693-698

(featured in Nature ‘News and Views’ and highlighted in Nature Chemical Biology)

​

103. Beyond DPPH: Use of Fluorescence-ENabled Inhibited AutoXidation (FENIX) to Predict

Oxidative Cell Death Rescue

Ron Shah, Luke Farmer, Omkar Zilka, Anthony T. M. Van Kessel & Derek A. Pratt*

Cell Chemical Biology 2019, 26, 1594-1607

(selected as a ‘Feature Article’ and highlighted in Cell Chem. Biol.)

​

102. Threshold Protective Effect of Deuterated Polyunsaturated Fatty Acids on the Peroxidation of Lipid Bilayers

Alexander M. Firsov, Maksim A. Fomich, Andrei V. Bekish, Olga L. Sharko, Elena A. Kotova, Harry J. Saal, Dragoslav Vidovic,

Vadim V. Shmanai, Derek A. Pratt, Yuri N. Antonenko* & Mikhail S. Shchepinov*

FEBS J. 2019, 286, 2099-2017

​

101. The Antioxidant Activity of Polysulfides: It’s Radical!

Jean-Philippe R. Chauvin, Markus Griesser & Derek A. Pratt*

Chemical Science 2019, 10, 4999-5010 

(selected as a ‘Hot Article’ and highlighted in the Royal Society of Chemistry’s Chemistry World)

​

100. H-Atom Abstraction vs. Addition: Accounting for the Diverse Product Distribution in the

Autoxidation of Cholesterol & its Esters

Zosia A. M. Zielinski & Derek A. Pratt*

Journal of the American Chemical Society 2019, 141, 3037-3051

​

2018

​

99. Electrochemical Dimerization of Phenylpropenoids and the Surprising Antioxidant Activity of the

Resultant Quinone Methide Dimers

Kevin J. Romero, Matthew S. Galliher, Irene Bosque, Mark A. R. Raycroft, Jean-Philippe R. Chauvin,

Derek A. Pratt* & Corey R. J. Stephenson*

Angewandte Chemie International Edition 2018, 57, 17125-17129

​

98. Radicals in Natural Product Synthesis

Kevin J. Romero, Matthew S. Galliher, Derek A. Pratt* & Corey R. J. Stephenson*

Chemical Society Reviews 2018, 47, 7851-7866

(invited tutorial review)

 

97. Recent Insights on Hydrogen Atom Transfer in the Inhibition of Hydrocarbon Autoxidation

Jia-Fei Poon & Derek A. Pratt*

Accounts of Chemical Research 2018, 51, 1996-2005

(invited for special issue on H-atom transfer)

​

96. The Hydrogen Atom Transfer Reactivity of Sulfinic Acids

Markus Griesser, Jean-Philippe R. Chauvin & Derek A. Pratt*

Chemical Science 2018, 9, 7218-7229

​

95. Inhibition of Hydrocarbon Autoxidation by Nitroxide-Catalyzed Cross-Dismutation of

Hydroperoxyl and Alkylperoxyl Radicals 

Kareem A. Harrison, Evan A. Haidasz, Markus Griesser & Derek A. Pratt*

Chemical Science 2018, 9, 6068-6079

 

94. The Catalytic Reaction of Nitroxides with Peroxyl Radicals its Relevance to their Cytoprotective Properties 

Markus Griesser, Ron Shah, Antonius T. M. Van Kessel, Omkar Zilka, Evan A. Haidasz & Derek A. Pratt*

Journal of the American Chemical Society 2018, 140, 3798-3808

​

93. Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

Ron Shah, Mikhail S. Shchepinov & Derek A. Pratt*

ACS Central Science 2018, 4, 387-396

(selected for an ACS Central Science ‘First Reaction’)

​

2017

​

92. Phenoxazine: A Privileged Scaffold for Radical-Trapping Antioxidants

Luke Farmer, Evan A. Haidasz, Markus Griesser & Derek A. Pratt*

Journal of Organic Chemistry 2017, 82, 10523-10536

​

91. The Potency of Diarylamine Radical-Trapping Antioxidants as Inhibitors of Ferroptosis Underscores

the Role of Autoxidation in Cell Death

Ron Shah, Kaitlyn D. Margison & Derek A. Pratt*

ACS Chemical Biology 2017, 12, 2538-2545

​

90. Hydroperosulfides: H-atom Transfer Agents Par Excellence

Jean-Philippe R. Chauvin, Markus Griesser & Derek A. Pratt*

Journal of the American Chemical Society 2017, 139, 6484-6493

(selected for a JACS ‘Spotlight’)

​

89. Diazaphenoxazines and Diazaphenothiazines: Synthesis of the ‘Correct’ Isomers Reveals They are

Highly Reactive Radical-Trapping Antioxidants

Evan A. Haidasz & Derek A. Pratt*

Organic Letters 2017, 19, 1854-1857

​

88. Lipid Peroxidation: Kinetics, Mechanisms and Products

Zosia A. M. Zielinski & Derek A. Pratt*

Journal of Organic Chemistry 2017, 82, 2817-2825

(invited ‘Synopsis’)

​

87. Aminyl Radical Generation via Tandem Norrish Type I Photocleavage, b-Fragmentation:

Independent Generation and Reactivity of the 2'-Deoxyadenosin-N6-yl Radical 

Liwei Zheng, Markus Griesser, Derek A. Pratt* & Marc M. Greenberg*

Journal of Organic Chemistry 2017, 82, 3571-3580

​

86. Ferroptosis Inhibition: Mechanisms and Opportunities 

José Pedro Friedmann Angeli,* Ron Shah, Derek A. Pratt & Marcus Conrad

Trends in Pharmaceutical Sciences 2017, 38, 489-498

​

85. The Radical-Trapping Antioxidant Activity of Ferrostatin-1 and Liproxstatin-1 Suggests that

Lipid Peroxidation (Autoxidation) Drives Ferroptotic Cell Death

Omkar Zilka, Ron Shah, Bo Li, José Pedro Friedmann Angeli, Markus Griesser, Marcus Conrad & Derek A. Pratt*

ACS Central Science 2017, 3, 232-243

(highlighted in Cell Chemical Biology)

​

84. On the Mechanism of Thiol, Sulfenic and Sulfinic Acid Oxidation by Hydrogen Peroxide

Jean-Philippe R. Chauvin & Derek A. Pratt*

Angewandte Chemie International Edition 2017, 56, 6255-6259

(highlighted in Nature Reviews Chemistry)

​